The 50 Major 'Grey's Anatomy' Characters

The half-sister of the series' protagonist, she first appears as a wide-eyed and insecure surgical intern, longing for acceptance from her estranged sibling. Over time, her exceptional intelligence, sincere kindness, and dogged determination earn her a place among the inner circle of doctors at Grey Sloan Memorial. Her tragic death in season 8 marks one of the most devastating and unforgettable moments in the show's history.

As a fiercely ambitious and highly skilled cardiothoracic surgeon, she consistently pushes herself and her peers to achieve greatness in their work. Her unapologetically competitive nature and unwillingness to compromise her career goals create both conflict and growth among her colleagues, while her tumultuous yet deeply loyal friendship with the titular character forms the emotional backbone of the show. Recognized for her sharp wit and dark sense of humor, she is an essential part of the series' unique blend of medical drama and lighthearted camaraderie.

Initially brash and antagonistic, this pediatric surgeon undergoes one of the most significant character transformations throughout the series, revealing hidden depths and evolving into a trusted friend and partner to his colleagues. His tumultuous upbringing and troubled relationships endear him to viewers as he learns to let down his guard and become a true team player. His final departure in season 16 offers a bittersweet sense of closure for fans who have watched him grow from an abrasive intern to an accomplished doctor.

Charmingly arrogant and unabashedly flirtatious, this plastic surgeon is often dismissed by his colleagues as nothing more than a superficial playboy. However, beneath his slick exterior is a compassionate doctor who goes above and beyond for his patients and friends. His complex relationships, particularly with the title character's sister Lexie and mentee Jackson, provide some of the most emotionally resonant moments on the show.

Often nicknamed "The Nazi" for her strict and demanding approach, this general surgeon quickly establishes herself as a force to be reckoned with among her trainees. Despite her tough exterior, she is fiercely protective of her interns, standing up for them when necessary and demonstrating a deep sense of responsibility for their personal and professional growth. Her own journey through struggles with mental health, marriage, and motherhood adds another compelling layer to her character, reinforcing the show's commitment to exploring complex, multifaceted female characters.

The series' titular character and protagonist, she consistently serves as the emotional core and moral compass of the show. Her resilience in the face of countless personal and professional challenges not only makes her a role model for other characters but also provides valuable commentary on the challenges facing modern working women. The evolution of her character, from a party-loving intern to a respected general surgeon and devoted mother, is both poignant and inspiring.